Dementia and Alzheimer’s Disease  

What is Dementia and Alzheimer’s Disease?

Dementia is a broad term that describes a group of neurodegenerative disorders affecting memory, thinking, and behavior. Alzheimer’s disease is the most common form of dementia, accounting for approximately 60–80% of cases. While environmental factors and lifestyle choices can influence the onset of the disease, genetic factors play a significant role in determining an individual’s risk.

Genes Analyzed in the Genetic Test

• APOE (Apolipoprotein E): The APOE ε4 allele significantly increases the risk of developing the disease, especially when present in two copies (ε4/ε4).
• APP (Amyloid Precursor Protein): Associated with the rare, familial form of the disease by affecting the accumulation of beta-amyloid in the brain.
• PSEN1 (Presenilin 1) & PSEN2 (Presenilin 2): Mutations in these genes lead to early-onset Alzheimer’s disease, typically occurring before the age of 60.

Why Choose This Test?

The genetic test for dementia and Alzheimer’s disease provides valuable insights that can aid in early diagnosis, prevention, and targeted management of the condition. By understanding your genetic predisposition, you and your healthcare provider can take proactive measures to manage risk factors and tailor treatment strategies effectively.