Weight Loss after Bariatric Surgery  

The polygenic test for weight loss after bariatric surgery is a specialized genetic analysis designed to assess an individual’s genetic predisposition to losing weight following bariatric surgery. This test provides valuable insights into how your body responds to the changes induced by the surgery and identifies the factors that may influence its success or failure.

How Does the Polygenic Test Work?

Bariatric surgery can be highly effective in reducing body weight, but not all patients experience the same results. Factors such as genetic background, dietary habits, lifestyle, and psychological aspects all contribute to the overall outcome. The polygenic test examines multiple genes responsible for regulating appetite, metabolism, and fat storage, thereby determining your genetic tendencies regarding weight loss. This analysis can estimate the likelihood of successful weight loss after surgery and guide the adjustment of therapeutic and nutritional strategies.

Genes Analyzed for Weight Loss

The polygenic test for weight loss after bariatric surgery evaluates 192 variants in 192 different genes related to post-surgical weight loss. Some of the key genes include:

• FTO (Fat Mass and Obesity Associated): This gene is linked to obesity predisposition and resistance to weight loss. Certain variants in FTO may make it more difficult to lose weight, even after surgery.
• MC4R (Melanocortin 4 Receptor): Involved in the regulation of appetite and energy balance, a variant in MC4R can affect your desire to eat and the body’s ability to burn calories.
• LEP (Leptin): Leptin plays a crucial role in regulating appetite and fat storage. Variants in the LEP gene or its receptor may contribute to resistance to weight loss.
• ADRB3 (Adrenergic Receptor Beta 3): This gene influences fat burning and overall energy expenditure. Variations in ADRB3 can impact the efficiency of calorie burning and reduction of body fat.
• PPARG (Peroxisome Proliferator-Activated Receptor Gamma): Associated with fat storage and insulin sensitivity, some variants in PPARG may increase the body’s tendency to store fat, thus affecting weight loss outcomes.

How Can the Polygenic Test Help?

The polygenic test offers personalized insights into how your body is likely to respond after bariatric surgery, enabling more effective weight management through tailored strategies. Benefits include:

• Personalized Nutritional Strategies: Specialists can develop customized dietary plans based on your genetic profile, optimizing post-surgical outcomes.
• Therapy Guidance: The analysis helps shape an appropriate therapeutic approach to address genetically determined issues with appetite regulation and weight control.
• Improved Outcomes: Understanding the genetic factors that influence weight loss can enhance the likelihood of successful weight reduction following surgery.
• Long-Term Weight Management Strategy: Ongoing monitoring and adjustments to your lifestyle and dietary habits, informed by your genetic predispositions, can help maintain your weight loss over time.

Why Choose the Polygenic Test?

By choosing the polygenic test for weight loss after bariatric surgery, you gain a deeper understanding of your genetic predispositions, allowing for a highly personalized therapeutic plan. This tailored approach not only boosts the chances of successful weight loss but also supports long-term healthy weight management.