Genetic Risk Assessment for Food Intolerances

According to published studies, genetic variants that affect the metabolism of fructose, lactose, and histamine are directly associated with the onset of gastrointestinal and systemic symptoms. Early genetic detection of these variants allows for accurate diagnosis and targeted dietary adjustments that reduce symptoms and improve quality of life.

GENOSOPHY®’s genetic test analyzes common genetic variants that impact the function of the ALDOB, LCT, and DAO enzymes. The test includes the analysis of 10 genetic variants, ensuring high accuracy in assessing genetic risk.

Who Is This Test For?

The test is recommended for:

• Individuals with unexplained gastrointestinal or systemic symptoms, such as bloating, diarrhea, headaches, etc.
• People who wish to understand their genetic risk and adjust their diet accordingly.

Clinical Benefits of GENOSOPHY®’s Genetic Analysis

Diagnosis

• More precise identification of individuals with increased genetic risk for food intolerances, enabling targeted follow-up and prevention.

Prognosis

• Early estimation of the likelihood of intolerance-related symptoms, supporting personalized dietary management.

Management

• Design of tailored dietary interventions based on individual genetic profiles.

Testing Procedure

1. Saliva sample collection
2. Analysis of 10 genetic variants and calculation of risk using GENOSOPHY®’s award-winning algorithm
3. Results delivered within 5–6 weeks

Supplementary Services

Based on the genetic testing results, GENOSOPHY® offers the following services to ensure optimal management of intolerances:

• Genetic counseling
• Customized nutrition plan based on the individual’s genetic profile
• Dietary consultations for targeted nutritional interventions

Selected References

• Ali et al., Hereditary Fructose Intolerance. J Med Genet 1998; 35:353–365
• Kim et al., Gut Liver 2021;15(1):142–145. DOI: 10.5009/gnl20189
• Mustonen et al., Am J Clin Nutr 2020;112:1036–1045. DOI: 10.1093/ajcn/nqaa215
• PMC Article on Genetic Intolerances

Note:
In rare cases of carbohydrate intolerances with a suspected genetic basis, where common pathogenic variants are not detected, exome sequencing is recommended to investigate less frequent pathogenic mutations in genes such as:

• ALDOB – Hereditary fructose intolerance
• GALT, GALK1, GALE – Galactosemia
• SI – Congenital sucrase-isomaltase deficiency
• SLC5A1 – Glucose/galactose malabsorption

And other rare metabolic disorders