Crohn’s Disease

According to published studies¹, individuals with a high genetic risk (top 30% of the population) are approximately 4 times more likely to develop Crohn’s disease compared to those at low genetic risk, especially if they follow an unhealthy dietary pattern. However, personalized nutrition, smoking cessation, regular physical activity, and maintaining a healthy body weight can significantly reduce the risk of developing the disease and help manage symptoms.

The GENOSOPHY® genetic test offers an advanced genetic screening for assessing Crohn’s disease risk. The test combines 40 genetic loci with GENOSOPHY®’s award-winning algorithm, ensuring high reliability in predicting genetic risk.

Conditions Covered by the Test

This test estimates the relative risk for Crohn’s disease and is recommended for:

Individuals with a family history of Crohn’s disease
People with symptoms related to Crohn’s who wish to assess their genetic predisposition

Clinical Benefits of GENOSOPHY®’s Polygenic Risk Score

Diagnosis

More accurate estimation of genetic risk for Crohn’s disease, offering valuable complementary information to existing diagnostic procedures

Prognosis

Ability to design preventive strategies through specialized protocols²
Studies show that a healthy lifestyle may halve the risk of disease, even in genetically predisposed individuals¹

Management

Design of personalized interventions in diet and lifestyle for more effective disease management

Testing Process

Saliva sample collection
Analysis of 40 genetic loci and calculation of relative risk using the GENOSOPHY® algorithm
Results delivered in 5–6 weeks

Supplementary Services

Based on each individual’s genetic test results and profile, GENOSOPHY® offers:

Genetic counseling
Personalized dietary plans
Nutritional consulting

References

Sun Y et al., Am J Gastroenterol 2023 Mar 1;118(3):511–522. DOI: 10.14309/ajg.0000000000002180
Pardali et al., Metabol Open 2024 Dec 30;25:100342. DOI: 10.1016/j.metop.2024.100342