{"id":2689,"date":"2025-03-18T09:21:20","date_gmt":"2025-03-18T09:21:20","guid":{"rendered":"https:\/\/genosophy.gr\/product\/muokardiopatheies\/"},"modified":"2025-04-24T14:12:26","modified_gmt":"2025-04-24T14:12:26","slug":"muokardiopatheies","status":"publish","type":"product","link":"https:\/\/genosophy.gr\/en\/product\/muokardiopatheies\/","title":{"rendered":"Cardiomyopathies"},"content":{"rendered":"<p>Cardiomyopathies are a heterogeneous group of serious cardiovascular diseases with a strong genetic basis, associated with an increased risk of heart failure and sudden cardiac death.<\/p>\n<p>GENOSOPHY\u00ae\u2019s <strong>Cardiomyopathy Genetic Test<\/strong> includes <strong>217 genes<\/strong>, offering comprehensive genetic evaluation useful for:<\/p>\n<ul>\n<li>Patients with a clinical diagnosis of cardiomyopathy of unknown cause<\/li>\n<li>Individuals with a family history of cardiomyopathy or sudden cardiac death<\/li>\n<li>Patients with unclear or overlapping cardiac symptoms<\/li>\n<li>Patients at high risk for serious complications, such as ventricular arrhythmias<\/li>\n<\/ul>\n<p>This genetic test complies with guidelines from all major international cardiology organizations, including the <strong>American College of Cardiology (ACC)<\/strong>, <strong>American Heart Association (AHA)<\/strong>, <strong>European Society of Cardiology (ESC)<\/strong>, <strong>Heart Failure Society of America (HFSA)<\/strong>, and <strong>Heart Rhythm Society (HRS)<\/strong>. These guidelines recommend genetic testing to support diagnosis, prognosis, and personalized management of patients with cardiomyopathies.<\/p>\n<h3>Conditions Covered by GENOSOPHY\u00ae\u2019s Cardiomyopathy Genetic Test<\/h3>\n<p>The test includes genes related to the following forms of cardiomyopathies:<\/p>\n<h4><strong>Hypertrophic Cardiomyopathy (HCM)<\/strong><\/h4>\n<ul>\n<li>The most common genetic heart condition, characterized by thickening of the heart muscle<\/li>\n<li>Associated with arrhythmias and an increased risk of sudden cardiac death<\/li>\n<\/ul>\n<h4>Dilated Cardiomyopathy (DCM)<\/h4>\n<ul>\n<li>Progressive enlargement and weakening of the myocardium<\/li>\n<li>Linked to heart failure and ventricular arrhythmias<\/li>\n<\/ul>\n<h4>Arrhythmogenic Cardiomyopathy (ARVC)<\/h4>\n<ul>\n<li>Progressive replacement of myocardium with fibrofatty tissue<\/li>\n<li>Increased risk of ventricular arrhythmias and sudden death<\/li>\n<\/ul>\n<h4>Left Ventricular Noncompaction Cardiomyopathy (LVNC)<\/h4>\n<ul>\n<li>A developmental disorder involving poor compaction of myocardial fibers<\/li>\n<li>Associated with heart failure and arrhythmias<\/li>\n<\/ul>\n<h3>Clinical Benefits<\/h3>\n<h4>Diagnosis<\/h4>\n<ul>\n<li>Genetic characterization of underlying causes<\/li>\n<li>Improves differential diagnosis and avoids unnecessary invasive procedures<\/li>\n<li>More accurate phenotypic classification in complex or atypical cases<\/li>\n<\/ul>\n<h4>Prognosis<\/h4>\n<ul>\n<li>Risk evaluation for sudden cardiac death<\/li>\n<li>Prediction of disease course and severity<\/li>\n<\/ul>\n<h3>Management<\/h3>\n<ul>\n<li>Guidance for medical and nutritional interventions, ICD, or pacemaker implantation<\/li>\n<li>Monitoring strategy and preventive interventions for relatives<\/li>\n<\/ul>\n<h3>Testing Procedure<\/h3>\n<p>The process is simple and includes:<\/p>\n<ol>\n<li>Collection of a blood or saliva sample<\/li>\n<li>Analysis of 217 cardiomyopathy-related genes using next-generation sequencing (NGS)<\/li>\n<li>Results available in 5\u20136 weeks<\/li>\n<\/ol>\n<p>Consultation and detailed explanation of genetic results is available through medical faculty from the <strong>National and Kapodistrian University of Athens (NKUA)<\/strong> as an additional service.<\/p>\n<h3>Genes Included in the Genetic Test<\/h3>\n<p><em>AARS2, ABCC6*, ABCC9, ACAD9, ACADVL, ACTA1, ACTA2, ACTC1, AKAP9, ANK2, APOA1, ATPAF2, BAG3, BRAF*, CACNA1C*, CACNA1D, CACNB2, CALM1*, CALM2, CALM3, CALR3, CAPN3, CASQ2, CASZ1, CAV3, CBL, CDH2, CHKB, CHRM2, COX15, CPT2, CRYAB, CSRP3, CTNNA3, DBH, DES, DMD, DNAJC19, DOLK, DPM3, DSC2, DSG2, DSP, DTNA, DYSF, EEF1A2, ELAC2, EMD, ENPP1, EPG5, ETFA, ETFB, ETFDH, FAH, FBXL4, FBXO32, FHL1*, FHOD3, FKRP, FKTN, FLNC*, FOXD4*, FOXRED1, FXN*, GAA, GATA4*, GATA6, GATAD1, GATC*, GBE1, GFM1, GLA, GLB1, GMPPB, GNB5, GSK3B, GTPBP3, GUSB*, HADHA, HAND1, HAND2, HCN4, HFE, HRAS, HCN4, IDUA, ILK, ISPD, JPH2, JUP, KCNA5, KCNE1, KCNE2, KCNH2, KCNJ2, KCNJ5, KCNQ1, KLHL24, KRAS*, LAMA2, LAMP2, LDB3, LMNA, LMOD2, LRRC10, LZTR1, MAP2K1, MAP2K2, MAP3K8, MIPEP*, MLYCD, MRPL3*, MRPL44, MRPS22, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-TE, MT-TF, MT-TG, MT-TH, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TN, MT-TP, MT-TQ, MT-TR, MT-TS1, MT-TS2, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, NDUFAF2, NDUFB11, NEXN, NF1*, NKX2-5, NONO, NOS1AP, NRAP, NRAS, NUP155, PCCA, PCCB*, PKP2*, PLEC, PLEKHM2, PLN, PNPLA2, PPA2, PPCS, PRKAG2, RBM20, RRAS, RYR2, SALL4, SCN10A, SCN1B, SCN3B, SCN5A, SCNN1B, SCNN1G, SCO1, SCO2, SDHA*, SELENON*, SGCA, SGCB, SGCD, SGCG, SHOC2, SLC12A3, SLC22A5, SLC25A20, SLC25A4, SMCHD1, SOS1, SOS2, TAB2, TANGO2, TAZ, TBX20*, TBX5, TCAP, TECRL, TGFB3, TMEM43, TMEM70, TNNC1, TNNI3, TNNI3K, TNNT2, TOR1AIP1, TPM1, TRDN, TRIM32, TRPM4, TSFM*, TTN*, TTR, VCL, VCP, VPS13A, XK<\/em><\/p>\n<p><strong>Note:<\/strong><br \/>\nIn addition to full exon sequencing of the above genes, the test also analyzes dozens of variants in non-coding regions, such as promoters and introns. Detection sensitivity for single nucleotide variants (SNVs), indels, and CNVs exceeds 99%. Sensitivity may be slightly reduced in genes marked with an asterisk (*).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cardiomyopathies are a heterogeneous group of serious cardiovascular diseases with a strong genetic basis, associated with an increased risk of heart failure and sudden cardiac death. GENOSOPHY\u00ae\u2019s Cardiomyopathy Genetic Test includes 217 genes, offering comprehensive genetic evaluation useful for: Patients with a clinical diagnosis of cardiomyopathy of unknown cause Individuals with a family history of [&hellip;]<\/p>\n","protected":false},"featured_media":2461,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[75],"product_tag":[],"class_list":{"0":"post-2689","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cardio-ipersies-gia-epaggelmaties-en","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product\/2689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media\/2461"}],"wp:attachment":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media?parent=2689"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_brand?post=2689"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_cat?post=2689"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_tag?post=2689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}