{"id":2691,"date":"2025-03-18T09:24:10","date_gmt":"2025-03-18T09:24:10","guid":{"rendered":"https:\/\/genosophy.gr\/product\/olokliromeno-kardiologiko-panel-2\/"},"modified":"2025-04-24T14:11:20","modified_gmt":"2025-04-24T14:11:20","slug":"olokliromeno-kardiologiko-panel-2","status":"publish","type":"product","link":"https:\/\/genosophy.gr\/en\/product\/olokliromeno-kardiologiko-panel-2\/","title":{"rendered":"Comprehensive Genetic Testing for Cardiovascular Diseases"},"content":{"rendered":"

Cardiovascular diseases are the leading cause of morbidity and mortality worldwide and have a strong genetic component. GENOSOPHY\u00ae<\/strong> offers a comprehensive genetic panel for cardiovascular conditions<\/strong>, with significant clinical utility in differential diagnosis, risk assessment, and targeted therapeutic intervention.<\/em><\/p>\n

The Comprehensive Cardiology Panel<\/strong> by GENOSOPHY\u00ae analyzes 260 genes<\/strong> using Next Generation Sequencing (NGS)<\/strong>, providing an extensive genetic evaluation for channelopathies, cardiomyopathies, arterial hypertension, dyslipidemia, and atherosclerosis. It also includes mitochondrial genome analysis to detect rare mitochondrial cardiomyopathies.<\/em><\/p>\n

The panel aligns with the guidelines of all major international cardiology societies, such as the American College of Cardiology (ACC)<\/strong>, American Heart Association (AHA)<\/strong>, European Society of Cardiology (ESC)<\/strong>, Heart Failure Society of America (HFSA)<\/strong>, and the Heart Rhythm Society (HRS)<\/strong>. These organizations recommend genetic testing to support diagnosis, prognosis, and personalized management of inherited cardiovascular disorders and arrhythmogenic syndromes.<\/em><\/p>\n

Who Should Consider Genetic Testing?<\/em><\/h3>\n

The Comprehensive Cardiology Panel is recommended for:<\/em><\/p>\n

    \n
  • Patients with a clinical diagnosis of cardiovascular disease of unknown cause<\/em><\/li>\n
  • Individuals with a family history of heart failure, sudden cardiac death, or early-onset atherosclerosis<\/em><\/li>\n
  • Patients with recurrent arrhythmias, syncope episodes, or unexplained cardiac events<\/em><\/li>\n
  • Young athletes or individuals predisposed to cardiac complications<\/em><\/li>\n
  • Individuals undergoing treatment for hypertension or dyslipidemia who seek a personalized pharmacogenetic approach<\/em><\/li>\n<\/ul>\n

    Conditions Covered by the GENOSOPHY\u00ae Panel<\/em><\/h3>\n

    The test includes genes related to:<\/em><\/p>\n

      \n
    • Coronary Artery Disease & Atherosclerosis<\/em><\/strong> \u2013 Genetic risk factors for heart attack and vascular disease<\/em><\/li>\n
    • Inherited Arrhythmias<\/em><\/strong> \u2013 Long QT Syndrome, Brugada Syndrome, CPVT<\/em><\/li>\n
    • Cardiomyopathies<\/em><\/strong> \u2013 Hypertrophic, Dilated, Arrhythmogenic, and LVNC<\/em><\/li>\n
    • Hypercholesterolemia & Lipid Disorders<\/em><\/strong> \u2013 Familial hypercholesterolemia, dyslipidemias<\/em><\/li>\n
    • Arterial Hypertension<\/em><\/strong> \u2013 Genetic contributors to blood pressure regulation<\/em><\/li>\n
    • Mitochondrial Heart Diseases<\/em><\/strong> \u2013 Mutations in mitochondrial DNA linked to rare cardiomyopathies<\/em><\/li>\n<\/ul>\n

      Clinical Benefits<\/em><\/h3>\n

      Diagnosis<\/em><\/h4>\n
        \n
      • Accurate genetic investigation for overlapping cardiovascular phenotype<\/em><\/li>\n
      • Supports differential diagnosis of cardiomyopathies, channelopathies, and vascular disease<\/em><\/li>\n
      • Detection of inherited forms of hypertension and lipid disorders<\/em><\/li>\n<\/ul>\n

        Prognosis<\/em><\/h4>\n
          \n
        • Evaluation of sudden cardiac death risk<\/em><\/li>\n
        • Prediction of disease progression and risk profile determination<\/em><\/li>\n<\/ul>\n

          Management<\/em><\/h4>\n
            \n
          • Guidance on personalized treatment (e.g., beta-blockers, antiarrhythmic agents, ICD implantation)<\/em><\/li>\n
          • Pharmacogenetic strategies for hypertension and dyslipidemia<\/em><\/li>\n
          • Cascade screening for at-risk family members and medical follow-up<\/em><\/li>\n<\/ul>\n

            Testing Procedure<\/em><\/h4>\n
              \n
            1. Sample collection (blood or saliva)<\/em><\/li>\n
            2. Whole exome analysis of 260 genes<\/strong> using NGS<\/em><\/li>\n
            3. Results delivered in 5\u20136 weeks<\/strong><\/em><\/li>\n<\/ol>\n

              Expert consultation<\/em><\/strong> and explanation of genetic results by professors from the National and Kapodistrian University of Athens (NKUA)<\/strong> is available as an additional service.<\/em><\/p>\n

              Genes Included in the Panel<\/em><\/h3>\n

              AARS2, ABCC6, ABCC9, ACAD9, ACADVL, ACTA1, ACTA2, ACTC1, ACTN2, AGK, AGL, AGPAT2, AKAP9, ALMS1*, ALPK3, ANK2, ANO5, APOA1, ATPAF2, BAG3, BRAF*, CACNA1C*, CACNA1D, CACNB2, CALM1*, CALM2, CALM3, CALR3, CAPN3, CASQ2, CASZ1, CBL, CDH2, CHKB, CHRM2, COX15, CPT2, CRYAB, CSRP3, CTNNA3, DBH, DES, DMD, DNAJC19, DOLK, DPM3, DSC2, DSG2, DSP, DTNA, DYSF, EEF1A2, ELAC2, EMD, ENPP1, EPG5, ETFA, ETFB, ETFDH, FAH, FBXL4, FBXO32, FHL1*, FHOD3, FKRP, FKTN, FLNC*, FOXD4*, FOXRED1, FXN*, GAA, GATA4*, GATA6, GATAD1, GATC*, GBE1, GFM1, GLA, GLB1, GMPPB, GNB5, GSK3B, GTPBP3, GUSB*, HADHA, HAND1, HAND2, HCN4, HFE, HRAS, IDUA, ILK, ISPD, JPH2, JUP, KCNA5, KCNE1, KCNE2, KCNH2, KCNJ2, KCNJ5, KCNQ1, KLHL24, KRAS*, LAMA2, LAMP2, LARGE, LDB3, LEMD2, LMNA, LMOD2, LRRC10, LZTR1, MAP2K1, MAP2K2, MAP3K8, MIPEP*, MLYCD, MRPL3*, MRPL44, MRPS22, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-RNR1, MT-RNR2, MT-TA, MT-TC, MT-TD, MT-TE, MT-TF, MT-TG, MT-TH, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TN, MT-TP, MT-TQ, MT-TR, MT-TS1, MT-TS2, MT-TT, MT-TV, MT-TW, MT-TY, MTO1*, MYBPC3, MYBPHL, MYH6, MYH7, MYL2, MYL3, MYL4, MYO18B, MYOT, MYPN, MYRF, NDUFAF2, NDUFB11, NEXN, NF1*, NKX2-5, NONO, NOS1AP, NRAP, NRAS, NUP155, PARS2, PCCA, PCCB*, PKP2*, PLEC, PLEKHM2, PLN, PNPLA2, POMT1, PPA2, PPCS, PPP1CB, PRDM16, PRKAG2, PTPN11, QRSL1, RAF1, RASA2, RBCK1, RBM20, RIT1, RMND1*, RRAS, RYR2, SALL4, SCN10A, SCN1B, SCN3B, SCN5A, SCNN1B, SCNN1G, SCO1, SCO2, SDHA*, SELENON*, SGCA, SGCB, SGCD, SGCG, SHOC2, SLC12A3, SLC22A5, SLC25A20, SLC25A3, SLC25A4, SMCHD1, SOS1, SOS2, SPEG, SPRED1, STAG2, TAB2, TANGO2, TAZ, TBX20*, TBX5, TCAP, TECRL, TGFB3, TMEM43, TMEM70, TNNC1, TNNI3, TNNI3K, TNNT2, TOR1AIP1, TPM1, TRDN, TRIM32, TRPM4, TSFM*, TTN*, TTR, VARS2, VCL, VCP, VPS13A, XK**<\/em><\/p>\n


              \nNote:<\/strong> In addition to the coding regions (exons), the test analyzes dozens of variants in non-coding regions (e.g., promoters, introns). Detection sensitivity for SNVs, indels, and CNVs exceeds 99%. Sensitivity may be slightly reduced in genes marked with an asterisk (*).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

              Cardiovascular diseases are the leading cause of morbidity and mortality worldwide and have a strong genetic component. GENOSOPHY\u00ae offers a comprehensive genetic panel for cardiovascular conditions, with significant clinical utility in differential diagnosis, risk assessment, and targeted therapeutic intervention. The Comprehensive Cardiology Panel by GENOSOPHY\u00ae analyzes 260 genes using Next Generation Sequencing (NGS), providing an […]<\/p>\n","protected":false},"featured_media":2461,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[75],"product_tag":[],"class_list":{"0":"post-2691","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cardio-ipersies-gia-epaggelmaties-en","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product\/2691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media\/2461"}],"wp:attachment":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media?parent=2691"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_brand?post=2691"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_cat?post=2691"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_tag?post=2691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}