{"id":2698,"date":"2025-03-18T09:24:16","date_gmt":"2025-03-18T09:24:16","guid":{"rendered":"https:\/\/genosophy.gr\/product\/sundromo-makrou-qt-2\/"},"modified":"2025-04-24T14:07:09","modified_gmt":"2025-04-24T14:07:09","slug":"sundromo-makrou-qt-2","status":"publish","type":"product","link":"https:\/\/genosophy.gr\/en\/product\/sundromo-makrou-qt-2\/","title":{"rendered":"Genetic Testing for Long QT Syndrome (LQTS)"},"content":{"rendered":"

Long QT Syndrome (LQTS)<\/strong> is a hereditary ion channel disorder that can lead to dangerous ventricular arrhythmias<\/strong>, syncope<\/strong>, or sudden cardiac death<\/strong>. The condition often manifests before the age of 40, and 10\u201315% of patients<\/strong> may experience sudden death.<\/p>\n

Genetic testing plays a diagnostic, prognostic, and therapeutic<\/strong> role, helping to identify pathogenic variants, guide treatment strategies, and manage at-risk family members.<\/p>\n

GENOSOPHY\u00ae\u2019s LQTS Genetic Panel<\/strong> includes 18 genes<\/strong> associated with inherited delays in cardiac repolarization. It is aligned with the guidelines of all major international cardiology organizations, including the American College of Cardiology (ACC)<\/strong>, American Heart Association (AHA)<\/strong>, European Society of Cardiology (ESC)<\/strong>, Heart Failure Society of America (HFSA)<\/strong>, and Heart Rhythm Society (HRS).<\/strong><\/p>\n

Conditions Covered by GENOSOPHY\u00ae’s LQTS Genetic Panel<\/h3>\n
    \n
  • Romano-Ward Syndrome<\/strong> \u2013 Classic LQTS without hearing loss<\/li>\n
  • Jervell and Lange-Nielsen Syndrome (JLNS)<\/strong> \u2013 LQTS with congenital deafness<\/li>\n
  • Timothy Syndrome<\/strong> \u2013 LQTS with co-occurring neurodevelopmental disorders<\/li>\n
  • Other genetic arrhythmopathies<\/strong> associated with QT prolongation<\/li>\n<\/ul>\n

    Clinical Benefits<\/h3>\n

    Diagnosis<\/h4>\n
      \n
    • Confirmation of the genetic cause<\/strong> in patients with prolonged QT<\/li>\n
    • Improved differential diagnosis<\/strong> between LQTS and other arrhythmogenic conditions<\/li>\n<\/ul>\n

      Prognosis<\/h4>\n
        \n
      • Assessment of sudden cardiac death risk<\/strong><\/li>\n
      • Definition of preventive strategies<\/strong> for at-risk relatives<\/li>\n<\/ul>\n

        Management<\/h4>\n
          \n
        • Pharmacogenetic guidance<\/strong> \u2013 Avoidance of QT-prolonging medications<\/li>\n
        • ICD implantation decisions<\/strong> in patients at high risk of ventricular arrhythmias<\/li>\n
        • Family screening<\/strong> and implementation of preventive strategies<\/strong><\/li>\n<\/ul>\n

          Testing Procedure<\/h4>\n
            \n
          1. Blood or saliva sample collection<\/strong><\/li>\n
          2. Analysis of 18 genes<\/strong> associated with LQTS using Next Generation Sequencing (NGS)<\/strong><\/li>\n
          3. Results available within ~5 weeks<\/strong><\/li>\n<\/ol>\n

            Genetic counseling<\/strong> and expert interpretation of results is available as an additional service by faculty members of the National and Kapodistrian University of Athens (NKUA).<\/strong><\/p>\n

            Genes Included in the Genetic Panel<\/h3>\n

            AKAP9, ANK2, CACNA1C*, CALM1*, CALM2, CALM3, CAV3, KCNE1, KCNE2, KCNH2, KCNJ2, KCNJ5, KCNQ1, NOS1AP, SCN5A, SLC12A3, TECRL, TRDN<\/strong><\/p>\n

            Note:<\/strong> In addition to full exon sequencing, GENOSOPHY\u00ae also analyzes dozens of non-coding variants<\/strong>, such as those in promoters and introns<\/strong>. Detection sensitivity for SNVs, indels, and CNVs is >99%<\/strong>. Sensitivity may be slightly lower for genes marked with an asterisk (*).<\/p>\n","protected":false},"excerpt":{"rendered":"

            Long QT Syndrome (LQTS) is a hereditary ion channel disorder that can lead to dangerous ventricular arrhythmias, syncope, or sudden cardiac death. The condition often manifests before the age of 40, and 10\u201315% of patients may experience sudden death. Genetic testing plays a diagnostic, prognostic, and therapeutic role, helping to identify pathogenic variants, guide treatment […]<\/p>\n","protected":false},"featured_media":2461,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[75],"product_tag":[],"class_list":{"0":"post-2698","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cardio-ipersies-gia-epaggelmaties-en","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product\/2698","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media\/2461"}],"wp:attachment":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media?parent=2698"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_brand?post=2698"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_cat?post=2698"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_tag?post=2698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}