{"id":2713,"date":"2025-03-18T11:16:53","date_gmt":"2025-03-18T11:16:53","guid":{"rendered":"https:\/\/genosophy.gr\/product\/diavitis-tupou-i-2\/"},"modified":"2025-04-24T13:54:56","modified_gmt":"2025-04-24T13:54:56","slug":"diavitis-tupou-i-2","status":"publish","type":"product","link":"https:\/\/genosophy.gr\/en\/product\/diavitis-tupou-i-2\/","title":{"rendered":"Type 1 Diabetes"},"content":{"rendered":"

Type 1 Diabetes \u2013 Genetic Risk Assessment<\/strong><\/p>\n

Type 1 Diabetes (T1D) is an autoimmune disease with a strong genetic component. According to recent studies, specific genetic variants\u2014particularly within the HLA complex<\/strong>\u2014significantly increase the risk of developing the disease, especially in children with a family history<\/strong> of T1D. Early genetic screening can identify newborns and infants at high genetic risk<\/strong>, allowing for timely monitoring and preventive strategies<\/strong> to help preserve pancreatic function.<\/p>\n

The GENOSOPHY\u00ae genetic test for Type 1 Diabetes<\/strong> is based on an enhanced polygenic risk score<\/strong> that incorporates 67 genetic variants<\/strong> and 18 HLA DR-DQ haplotype interactions<\/strong>. This improved score is 50% more accurate<\/strong> than older polygenic models and nearly twice as effective<\/strong> as simple HLA typing for neonatal screening. Analysis is performed using GENOSOPHY\u00ae\u2019s award-winning algorithm<\/strong>, ensuring high accuracy in estimating genetic risk.<\/p>\n

Who should consider this test?<\/h3>\n

Recommended for:
\n\u2022 Newborns and infants<\/strong> with a family history of Type 1 Diabetes<\/strong>
\n\u2022 Infants with autoantibodies<\/strong> linked to T1D, to assess the risk of disease progression
\n\u2022 Families<\/strong> who wish to know their child\u2019s genetic predisposition and adapt their medical follow-up accordingly<\/p>\n

Clinical Benefits of GENOSOPHY\u00ae’s Genetic Analysis<\/h3>\n

Diagnosis<\/h4>\n
    \n
  • Improved detection of newborns and infants with elevated genetic risk<\/strong> for Type 1 Diabetes<\/li>\n<\/ul>\n

    Prognosis<\/h4>\n
      \n
    • Estimation of the likelihood of developing T1D<\/strong> during childhood<\/li>\n
    • Supports early medical monitoring and follow-up<\/strong><\/li>\n<\/ul>\n

      Management<\/h4>\n
        \n
      • Tailored preventive strategies based on the child\u2019s genetic profile<\/li>\n
      • Family guidance<\/strong> on risk reduction and early lifestyle modifications<\/li>\n<\/ul>\n

        Test Procedure<\/h3>\n
          \n
        1. Collection of a saliva sample<\/strong> from the newborn or infant<\/li>\n
        2. Analysis of genetic variants and calculation of risk<\/strong> using GENOSOPHY\u00ae\u2019s algorithm<\/li>\n
        3. Delivery of results in 5\u20136 weeks<\/strong><\/li>\n<\/ol>\n

          Complementary Services<\/h3>\n

          Based on test results, GENOSOPHY\u00ae offers:
          \n\u2022 Genetic counseling<\/strong>
          \n\u2022 Personalized diet plans<\/strong> based on genetic profile
          \n\u2022 Nutritional consultation<\/strong><\/p>\n

          Key Reference<\/h3>\n
            \n
          1. Sharp et al., Diabetes Care<\/em>, 2019;42(2):200-207.
            \nDOI: 10.2337\/dc18-1785<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

            Type 1 Diabetes \u2013 Genetic Risk Assessment Type 1 Diabetes (T1D) is an autoimmune disease with a strong genetic component. According to recent studies, specific genetic variants\u2014particularly within the HLA complex\u2014significantly increase the risk of developing the disease, especially in children with a family history of T1D. Early genetic screening can identify newborns and infants […]<\/p>\n","protected":false},"featured_media":2463,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[81],"product_tag":[],"class_list":{"0":"post-2713","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-metabolic-ipiresies-gia-epaggelmaties-en","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product\/2713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media\/2463"}],"wp:attachment":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media?parent=2713"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_brand?post=2713"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_cat?post=2713"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_tag?post=2713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}