{"id":2716,"date":"2025-03-18T11:16:49","date_gmt":"2025-03-18T11:16:49","guid":{"rendered":"https:\/\/genosophy.gr\/product\/monogonidiaki-paxisarkia\/"},"modified":"2025-04-24T13:58:05","modified_gmt":"2025-04-24T13:58:05","slug":"monogonidiaki-paxisarkia","status":"publish","type":"product","link":"https:\/\/genosophy.gr\/en\/product\/monogonidiaki-paxisarkia\/","title":{"rendered":"Monogenic Obesity"},"content":{"rendered":"

MC4R Monogenic Obesity Genetic Test<\/strong><\/p>\n

Monogenic obesity is a group of rare genetic disorders characterized by severe, early-onset obesity<\/strong> as a primary feature. Pathogenic variants in the MC4R gene<\/strong> are among the most common causes of non-syndromic monogenic obesity<\/strong>, affecting appetite regulation and metabolism through hypothalamic pathways.<\/p>\n

Detection of MC4R variants can be done individually<\/strong> or as part of the GENOSOPHY\u00ae Monogenic Obesity Panel<\/strong>, which also includes genes such as LEP, LEPR, POMC, and PCSK1<\/strong> involved in energy balance and appetite regulation.<\/p>\n

Conditions Covered by the GENOSOPHY\u00ae Genetic Test<\/h3>\n

The test detects pathogenic variants in the MC4R gene<\/strong>, associated with:<\/p>\n

    \n
  • Severe early-onset obesity<\/strong> (BMI > 3 SD in children, BMI > 40 in adults)<\/li>\n
  • Hyperphagia and impaired satiety<\/strong><\/li>\n
  • Accelerated growth and increased lean body mass<\/strong><\/li>\n
  • Higher risk of metabolic complications<\/strong> (e.g., type 2 diabetes, hypertension)<\/li>\n<\/ul>\n

    Who Should Consider This Test?<\/h3>\n
      \n
    • Individuals with severe early-onset obesity<\/strong><\/li>\n
    • Children with rapid weight gain and overeating<\/strong><\/li>\n
    • Patients with a family history<\/strong> of early-onset obesity, especially with autosomal dominant inheritance patterns<\/strong><\/li>\n
    • Individuals with low energy expenditure<\/strong> or resistance to weight loss<\/strong><\/li>\n
    • People with impaired satiety<\/strong> or comorbid conditions<\/strong> like type 2 diabetes, hypertension, or dyslipidemia<\/li>\n<\/ul>\n

      Clinical Benefits<\/h3>\n

      Diagnosis<\/h4>\n
        \n
      • Confirmation of a genetic cause<\/strong> of severe obesity<\/li>\n
      • Differential diagnosis between monogenic<\/strong> and polygenic<\/strong> forms of obesity<\/li>\n<\/ul>\n

        Prognosis<\/h4>\n
          \n
        • Assessment of future risk for metabolic complications<\/strong><\/li>\n
        • Guidance for personalized prevention strategies<\/strong><\/li>\n<\/ul>\n

          Management<\/h4>\n
            \n
          • Targeted pharmacological interventions<\/strong> (e.g., GLP-1 receptor agonists)<\/li>\n
          • Precision nutritional interventions<\/strong> \u2013 see GENOSOPHY\u00ae’s personalized nutrition support services<\/li>\n
          • Family genetic counseling<\/strong><\/li>\n<\/ul>\n

            Test Procedure<\/h3>\n
              \n
            1. Saliva or blood sample collection<\/strong><\/li>\n
            2. Analysis of the MC4R gene<\/strong> using Next-Generation Sequencing (NGS)<\/strong><\/li>\n
            3. Results delivered within approximately 5 weeks<\/strong><\/li>\n<\/ol>\n

              Optional:<\/strong> Expert genetic counseling<\/strong> and result interpretation<\/strong> by Professors of the National and Kapodistrian University of Athens (EKPA), available as a separate service.<\/p>\n","protected":false},"excerpt":{"rendered":"

              MC4R Monogenic Obesity Genetic Test Monogenic obesity is a group of rare genetic disorders characterized by severe, early-onset obesity as a primary feature. Pathogenic variants in the MC4R gene are among the most common causes of non-syndromic monogenic obesity, affecting appetite regulation and metabolism through hypothalamic pathways. Detection of MC4R variants can be done individually […]<\/p>\n","protected":false},"featured_media":2463,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[81],"product_tag":[],"class_list":{"0":"post-2716","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-metabolic-ipiresies-gia-epaggelmaties-en","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product\/2716","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media\/2463"}],"wp:attachment":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media?parent=2716"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_brand?post=2716"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_cat?post=2716"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_tag?post=2716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}