{"id":2737,"date":"2025-03-18T11:52:05","date_gmt":"2025-03-18T11:52:05","guid":{"rendered":"https:\/\/genosophy.gr\/product\/karkinos-tou-paxeos-enterou-2\/"},"modified":"2025-04-24T13:32:40","modified_gmt":"2025-04-24T13:32:40","slug":"karkinos-tou-paxeos-enterou-2","status":"publish","type":"product","link":"https:\/\/genosophy.gr\/en\/product\/karkinos-tou-paxeos-enterou-2\/","title":{"rendered":"Colorectal Cancer \u2013 Genetic Testing"},"content":{"rendered":"

Colorectal cancer is a multifactorial disease<\/strong>, with hereditary predisposition<\/strong> playing a significant role. Lynch Syndrome<\/strong> is the most common inherited form of colorectal cancer, while other genetic conditions such as FAP, MAP<\/strong>, and Peutz-Jeghers syndrome<\/strong> also increase cancer risk.<\/p>\n

The GENOSOPHY\u00ae Genetic Test for Hereditary Colorectal Cancer<\/strong> includes 23 genes<\/strong>, offering comprehensive genetic screening for inherited cancer syndromes.<\/p>\n

Conditions Covered by the Genetic Test<\/h3>\n
    \n
  • Lynch Syndrome<\/strong>: Significantly increases the risk of colon, rectal, and endometrial cancers.<\/li>\n
  • Familial Adenomatous Polyposis (FAP)<\/strong>: Causes hundreds of polyps, which if left untreated, almost always progress to cancer.<\/li>\n
  • MUTYH-Associated Polyposis (MAP)<\/strong>: Leads to multiple adenomas and elevated colorectal cancer risk.<\/li>\n
  • Peutz-Jeghers Syndrome<\/strong>: Causes polyps throughout the gastrointestinal tract and increases risk for several types of cancer.<\/li>\n
  • Juvenile Polyposis Syndrome<\/strong>: Characterized by multiple polyps and an increased risk of gastrointestinal cancers.<\/li>\n
  • Other hereditary cancer syndromes.<\/li>\n<\/ul>\n

    Clinical Benefits<\/h3>\n

    Diagnosis<\/h4>\n
      \n
    • Identification of pathogenic variants<\/strong> associated with increased colorectal cancer risk<\/li>\n
    • Differentiation<\/strong> between sporadic and hereditary cancer forms<\/li>\n<\/ul>\n

      Prognosis<\/h4>\n
        \n
      • Assessment of individual and familial cancer risk<\/strong><\/li>\n
      • Guidance on preventive monitoring<\/strong> and early therapeutic interventions<\/strong><\/li>\n<\/ul>\n

        Management<\/h4>\n
          \n
        • Decision-making regarding enhanced surveillance<\/strong> or preventive procedures<\/strong><\/li>\n
        • Support in treatment strategy planning<\/strong><\/li>\n<\/ul>\n

          Testing Procedure<\/h3>\n
            \n
          1. Sample collection<\/strong> (blood or saliva)<\/li>\n
          2. NGS analysis<\/strong> of 23 genes<\/strong> linked to hereditary colorectal cancer<\/li>\n
          3. Results available in approximately 5 weeks<\/strong><\/li>\n<\/ol>\n

            Comprehensive genetic counseling and interpretation<\/strong> are available from Professors at the National and Kapodistrian University of Athens (EKPA)<\/strong> as an optional service.<\/p>\n

            Genes Included in the Test<\/h3>\n

            APC, AXIN2, BLM, BMPR1A*, CDH1, EPCAM, GALNT12, GREM1, MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2*, POLD1, POLE, PTEN*, RPS20, SMAD4, STK11, TP53<\/strong><\/p>\n

            Note:<\/strong> In addition to all coding exons, the GENOSOPHY\u00ae test examines dozens of non-coding variants<\/strong>, such as promoters and introns, which may hold clinical value. The detection sensitivity for SNVs, indels, and CNVs<\/strong> is >99%<\/strong>, with slightly reduced sensitivity for genes marked with an asterisk (*).<\/p>\n

            The GENOSOPHY\u00ae Hereditary Colorectal Cancer Panel<\/strong> offers a reliable and advanced genetic investigation<\/strong>, supporting both cancer prevention<\/strong> and personalized patient management<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

            Colorectal cancer is a multifactorial disease, with hereditary predisposition playing a significant role. Lynch Syndrome is the most common inherited form of colorectal cancer, while other genetic conditions such as FAP, MAP, and Peutz-Jeghers syndrome also increase cancer risk. The GENOSOPHY\u00ae Genetic Test for Hereditary Colorectal Cancer includes 23 genes, offering comprehensive genetic screening for […]<\/p>\n","protected":false},"featured_media":2462,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[85],"product_tag":[],"class_list":{"0":"post-2737","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-oncologic-ipiresies-gia-epaggelmaties-en","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product\/2737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media\/2462"}],"wp:attachment":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media?parent=2737"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_brand?post=2737"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_cat?post=2737"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_tag?post=2737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}