{"id":2741,"date":"2025-03-18T11:52:08","date_gmt":"2025-03-18T11:52:08","guid":{"rendered":"https:\/\/genosophy.gr\/product\/klironomikos-karkinos-tou-mastou-brca1-kai-brca2\/"},"modified":"2025-04-24T13:23:14","modified_gmt":"2025-04-24T13:23:14","slug":"klironomikos-karkinos-tou-mastou-brca1-kai-brca2","status":"publish","type":"product","link":"https:\/\/genosophy.gr\/en\/product\/klironomikos-karkinos-tou-mastou-brca1-kai-brca2\/","title":{"rendered":"Hereditary Breast Cancer (BRCA1 & BRCA2)"},"content":{"rendered":"

Inherited mutations in the BRCA1 and BRCA2 genes<\/strong> significantly increase the lifetime risk of developing breast cancer (40\u201380%)<\/strong>, ovarian cancer (11\u201340%)<\/strong>, and other malignancies.<\/p>\n

The GENOSOPHY\u00ae Hereditary Breast Cancer Genetic Panel<\/strong> includes sequencing of 9 genes<\/strong> associated with elevated risk for these cancers.<\/p>\n

Conditions Covered by the Genetic Test<\/h3>\n
    \n
  • Hereditary Breast and Ovarian Cancer (HBOC Syndrome \u2013 BRCA1\/2)<\/strong><\/li>\n
  • Pancreatic and Prostate Cancer<\/strong> (associated with BRCA2 and PALB2)<\/li>\n
  • Li-Fraumeni Syndrome<\/strong> (TP53) \u2013 Linked to breast cancer and various other tumors<\/li>\n
  • Cowden Syndrome<\/strong> (PTEN) \u2013 Increased risk for breast and endometrial cancer<\/li>\n
  • Peutz-Jeghers Syndrome<\/strong> (STK11) \u2013 Increased risk for breast and ovarian cancer<\/li>\n<\/ul>\n

    Clinical Benefits<\/h3>\n

    Diagnosis<\/h4>\n
      \n
    • Detection of pathogenic genetic variants<\/strong> associated with breast and ovarian cancer<\/li>\n
    • Differentiation between sporadic and hereditary<\/strong> cancer cases<\/li>\n<\/ul>\n

      Prognosis<\/h4>\n
        \n
      • Accurate risk assessment<\/strong> for cancer development and proactive strategy planning<\/li>\n
      • Family-based genetic counseling and risk evaluation<\/strong><\/li>\n<\/ul>\n

        Management<\/h4>\n
          \n
        • Personalized surveillance and guidance on prophylactic surgery<\/strong><\/li>\n
        • Pharmacogenetic approach<\/strong>, e.g., PARP inhibitor therapy for BRCA mutation carriers<\/li>\n<\/ul>\n

          Testing Procedure<\/h3>\n
            \n
          1. Sample collection<\/strong> (blood or saliva)<\/li>\n
          2. Next-Generation Sequencing (NGS)<\/strong> of 9 genes linked to hereditary breast cancer<\/li>\n
          3. Results available within approximately 5 weeks<\/strong><\/li>\n<\/ol>\n

            Genetic counseling and results interpretation<\/strong> by Professors of the National and Kapodistrian University of Athens (EKPA) is offered as a separate service.<\/p>\n

            Genes Included in the Panel<\/h3>\n

            BRCA1*, BRCA2, CDH1, MAP3K1, PALB2, PTEN*, RECQL*, STK11, TP53<\/strong><\/p>\n

            Note:<\/strong> In addition to full exon sequencing, the GENOSOPHY\u00ae test also analyzes non-coding regions<\/strong> such as promoters and introns<\/strong>, which may contain clinically relevant variants.
            \nThe detection sensitivity<\/strong> for SNVs, indels, and CNVs<\/strong> is >99%<\/strong>. Slightly reduced sensitivity may apply to genes marked with an asterisk (*).<\/p>\n","protected":false},"excerpt":{"rendered":"

            Inherited mutations in the BRCA1 and BRCA2 genes significantly increase the lifetime risk of developing breast cancer (40\u201380%), ovarian cancer (11\u201340%), and other malignancies. The GENOSOPHY\u00ae Hereditary Breast Cancer Genetic Panel includes sequencing of 9 genes associated with elevated risk for these cancers. Conditions Covered by the Genetic Test Hereditary Breast and Ovarian Cancer (HBOC […]<\/p>\n","protected":false},"featured_media":2462,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[85],"product_tag":[],"class_list":{"0":"post-2741","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-oncologic-ipiresies-gia-epaggelmaties-en","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product\/2741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media\/2462"}],"wp:attachment":[{"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/media?parent=2741"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_brand?post=2741"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_cat?post=2741"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/genosophy.gr\/en\/wp-json\/wp\/v2\/product_tag?post=2741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}