Alzheimer’s Disease

What is Alzheimer’s Disease?

Alzheimer’s disease is a progressive neurodegenerative disorder that affects memory, thinking, and behavior. A significant genetic risk factor is the APOE (Apolipoprotein E) gene, which is involved in lipid metabolism and neurological function.

The Role of the APOE Gene

The APOE gene has three main allelic variations:

• APOE ε2: Associated with a lower risk of developing Alzheimer’s disease.
• APOE ε3: Considered the neutral form, with neither an increased nor decreased risk.
• APOE ε4: Linked to an increased risk of developing Alzheimer’s disease, especially in individuals who inherit two copies (ε4/ε4).

Why Choose This Test?

Detecting the APOE ε4 allele can help assess the risk of developing Alzheimer’s disease, although it is not a diagnostic test. Genetic testing is especially useful for individuals with a family history of Alzheimer’s, allowing for early preventive measures.