Weight Loss After Bariatric Surgery

Genetic Profile Assessment and Weight Loss

According to published studies, the likelihood of not achieving desired weight loss after bariatric surgery varies among patients and is influenced by factors such as initial BMI, age, sex, surgical technique, and genetic background.
The inclusion of a Polygenic Risk Score (PRS) significantly improves predictive accuracy, reducing the rate of false negative predictions from 20.4% to 10.9%, allowing for timely intervention and better outcomes.

The GENOSOPHY® genetic test analyzes 192 genetic variants, providing a personalized estimate of a patient’s response to surgery, thus supporting more informed clinical decisions and optimizing both pre- and post-operative strategies.

Who is this test for?

This test is recommended for:
• Individuals scheduled for bariatric surgery who wish to understand their genetic likelihood of successful long-term weight loss.
• Healthcare professionals seeking to personalize surgical decisions and postoperative care plans.

Clinical Benefits of the GENOSOPHY® Polygenic Risk Score

Diagnosis

• Identification of individuals with genetic traits linked to reduced weight loss, enabling early intervention and care plan adjustment.

Prognosis

• Reliable prediction of weight loss rate and likelihood of maintaining weight loss long term.

Management

• Tailored post-operative strategies including personalized diet and exercise plans to improve success after surgery.

Test Procedure

1. Saliva sample collection
2. Analysis of 192 genetic markers and PRS calculation using the award-winning GENOSOPHY® algorithm
3. Results delivered within 5–6 weeks

Additional Services

Based on the genetic profile, GENOSOPHY® offers:
• Genetic counseling
• Nutrition planning based on genetic predisposition
• Personalized dietary consultations

Key Reference

de Toro-Martín et al., JCI Insight 2018; 3(17): e122011
DOI: 10.1172/jci.insight.122011