Ulcerative colitis is a chronic inflammatory bowel disease (IBD) that affects the colon and rectum, causing symptoms such as diarrhea, abdominal pain, fatigue, and weight loss. Although the exact cause of ulcerative colitis is not fully understood, it is known that genetic, environmental, and immunological factors play significant roles in its development.
Genetic testing can help identify genetic factors that increase sensitivity to ulcerative colitis, contributing to better diagnosis, prevention, and personalized treatment.
The genetic test for ulcerative colitis aims to identify mutations in genes associated with inflammatory bowel disease. A total of 42 genetic loci are analyzed to calculate the genetic risk of developing ulcerative colitis. The analysis results are available within 5-6 weeks from the collection of the sample at the laboratory. The test is performed through a painless procedure using oral swabs.
Ulcerative colitis is associated with genetic variations that affect the immune system and the inflammatory response. The genes analyzed include:
Identifying these genetic variations helps in better understanding the risk and progression of the disease.
It aids in distinguishing ulcerative colitis from other inflammatory bowel diseases, such as Crohn’s disease.
The test detects genetic variations that influence the response to treatments, such as immunosuppressants and biological drugs (e.g., anti-TNF).
It can guide doctors in choosing medications and prevent the trial of ineffective treatments.
It identifies individuals at high genetic risk, helping with monitoring and early intervention before severe symptoms appear.
If there is a family history of ulcerative colitis, the test can determine whether an individual or their children have a genetic predisposition to the disease.
The test can be performed at any time, regardless of whether the patient follows a special diet or is experiencing active symptoms.
The genetic test is conducted with an oral swab, avoiding the need for blood draws or other invasive methods.
Early detection of risk can lead to preventive measures, such as dietary changes, avoiding smoking, and regular medical monitoring.
The test results can support the choice of personalized treatments, improving the effectiveness of the therapy.
