Crohn’s disease is a chronic inflammatory condition of the gastrointestinal tract and is classified among the Inflammatory Bowel Diseases (IBD). It causes inflammation that can affect any part of the digestive system—from the mouth to the anus—although it most often affects the small intestine and the colon.
The genetic test for Crohn’s disease analyzes 40 genetic loci and uses a specialized algorithm to calculate the genetic risk for developing Crohn’s disease. It will confirm whether you have the genes associated with an increased risk of the disease. Individuals with a high genetic risk, as identified through this specific test, have about 4.44 times greater likelihood of developing Crohn’s disease compared to those with a low genetic risk. The analysis results are ready within 5-6 weeks from the receipt of the samples at the laboratory.
Crohn’s disease has a strong genetic component, as individuals with a family history of the disease are at increased risk of developing it. There are several genes that have been linked to Crohn’s disease, and mutations in these genes may contribute to its development. The main genes involved in Crohn’s disease include:
Although these genes increase the risk, Crohn’s disease is not entirely genetically determined. Environmental factors (such as smoking, diet, and infections) play an important role in triggering the disease in genetically predisposed individuals.
Genetic testing can help by determining:
The genetic test offers several specific advantages:
Genetic testing in children is useful if many family members (e.g., parents or siblings) have been diagnosed with Crohn’s disease or other inflammatory bowel diseases. It is also beneficial in conjunction with clinical and laboratory examinations in cases where a child exhibits symptoms such as chronic diarrhea, abdominal pain, unexplained weight loss, or anemia.
