Comprehensive Obesity Management

Obesity is a multifactorial condition influenced by both environmental factors and genetic predisposition. A polygenic obesity test allows for the analysis of genes that affect metabolism, appetite, and weight loss or regain, offering personalized recommendations for more effective management.

The test covers four key areas:

• Obesity: Analysis of genetic factors that affect fat storage, calorie burning, and the tendency to gain weight.
• Weight Regain: Determines the predisposition to regain weight after loss, helping to create personalized strategies for maintaining results.
• Emotional Eating (Dopamine): Evaluates genetic markers related to how dopamine influences eating behavior, providing insights into the impact of stress and reward on food intake.
• Carbohydrate Metabolism: Analyzes how the body metabolizes carbohydrates, affecting glucose levels and response to different dietary patterns.

Which Genes Are Tested?

The comprehensive genetic test for obesity management examines genes involved in metabolism, appetite regulation, weight control, and eating behavior. Some of the key genes include:

• FTO: Associated with fat storage, body mass index (BMI), and a tendency toward overeating.
• MC4R: Influences appetite and the regulation of energy balance.
• LEPR: Encodes the leptin receptor, affecting satiety and food intake.
• PPARG: Involved in the regulation of lipogenesis and insulin sensitivity.
• ADRB2 & ADRB3: Participate in the regulation of lipolysis and the body’s response to physical activity.
• UCP1: Related to thermogenesis and metabolic rate.
• DRD2: Linked to the brain’s reward system and the tendency to overeat due to emotional stimuli.
• COMT: Affects dopamine metabolism and stress management, which can influence eating behavior.
• AMY1: Encodes amylase, the enzyme that breaks down carbohydrates, affecting the body’s response to high- or low-carbohydrate diets.
• TCF7L2: Associated with the risk of type 2 diabetes and the body’s ability to regulate blood glucose levels.

How Can This Genetic Test Help?

Based on the test results, personalized recommendations can be made regarding:

• Nutrition: Selection of the optimal macronutrient composition and food choices tailored to the individual’s genetic profile.
• Exercise: Customization of the type, intensity, and duration of physical activity based on genetic predisposition.
• Pharmacological Support: Guidance on the likely response to specific medications for managing obesity.

The polygenic obesity management test enables targeted interventions, contributing to improved overall health and long-term weight maintenance.