Cardiovascular Disease Prevention

Cardiovascular diseases are the leading cause of death worldwide. The genetic test for the prevention of cardiovascular diseases detects mutations that affect factors such as:

• Blood pressure
• Levels of cholesterol and triglycerides
• Thrombotic predisposition
• Inflammatory responses associated with atherosclerosis

Which Genes Are Tested?

Polygenic Hypertension Panel

• ACE (Angiotensin-Converting Enzyme): Regulates blood pressure through the renin-angiotensin system.
• AGT (Angiotensinogen): Involved in blood pressure regulation and associated with an increased risk of hypertension.
• NOS3 (Endothelial Nitric Oxide Synthase): Regulates the dilation of blood vessels.
• ADD1 (Adducin 1): Influences sodium reabsorption in the kidneys and is associated with hypertension.

Polygenic Dyslipidemia Panel

• APOE (Apolipoprotein E): Regulates lipid metabolism and is linked to high LDL levels and atherosclerosis.
• LDLR (Low-Density Lipoprotein Receptor): Affects the removal of LDL cholesterol from the blood.
• PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9): Regulates the degradation of LDL receptors and influences cholesterol levels.
• CETP (Cholesteryl Ester Transfer Protein): Involved in HDL cholesterol metabolism.

Genetic Test for Thrombosis

• F5 (Factor V Leiden): A mutation that increases the predisposition to thrombosis.
• F2 (Prothrombin, G20210A): Increases the likelihood of thrombosis.
• MTHFR (Methylenetetrahydrofolate Reductase): Associated with elevated homocysteine levels, which heighten the risk of vascular diseases.
• SERPINE1 (PAI-1): Regulates fibrinolysis and is linked to increased thrombogenicity.

Genetic Test for Cardiovascular Diseases

• LPA (Lipoprotein(a)): Elevated levels are associated with a high risk of cardiovascular diseases.
• ABCA1 (ATP-Binding Cassette Transporter A1): Regulates cholesterol transport and affects HDL levels.
• KCNJ11 (Potassium Voltage-Gated Channel): Associated with metabolic disorders that impact heart function.
• SCARB1 (Scavenger Receptor Class B Type 1): Influences the uptake of HDL cholesterol by the liver.

Why Choose This Test?

Identifying these genetic predispositions allows for personalized interventions, such as tailored diets, targeted medications (e.g., statins, anticoagulants), and close medical monitoring, all aimed at reducing the risk of cardiovascular events.